During digestion, carbohydrates are broken down into smaller sugar molecules (glucose), which are absorbed into the blood. When the glucose level in the blood increases, the body will release the hormone insulin. Increased insulin levels lead to fat storage and weight gain.
If glucose is constantly increased due to diet or lifestyle factors, insulin production will also be constantly active. This allows our cells to become 'numb' to insulin. This is called insulin resistance. It means that more and more circulating insulin is needed to get glucose into the cells, leading to higher baseline insulin levels. High insulin prevents the body from burning triglycerides (fat). What if insulin levels never really drop enough to signal that the body should burn the stored fat? This process directly counteracts weight loss efforts.

On the other hand, low glucose levels lead to lower insulin levels, which can lead to weight loss and reduced fat mass.
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